カワムラ　クニオ   KAWAMURA Kunio   川村　邦男    所属   広島修道大学  人間環境学部    職種   教授
言語種別	英語
発行・発表の年月	2022/05
形態種別	学術論文
査読	査読有り
標題	Nano-pulsed discharge-plasma-induced abiotic oligopeptide formation from diketopiperazine
執筆形態	共著
掲載誌名	Naturwissenschaften
掲載区分	国外
巻・号・頁	109
頁数	6
担当範囲	Corresponding author
著者・共著者	Mitsuru Sasaki*, Yuji Miyagawa, Kouki Nonaka, Ryota Miyanomae, Armando T. Quitain, Tetsuya Kida, Motonobu Goto, Tetsuo Honma, Tomohiro Furusato, Kunio Kawamura*
概要	Conventional oligopeptide synthesis techniques involve environmentally harmful procedures and materials. In addition, the efficient accumulation of oligopeptides under Hadean Earth environments regarding the origin of life remains still unclear. In these processes, the formation of diketopiperazine is a big issue due to the strong inhibition for further elongation beyond dipeptides. Here, we show an efficient pathway for oligopeptide formation using a specially designed experimental setup to run both thermal and non-thermal dis- charge plasma, generated by nano-pulsed electric discharge with 16–23 kV voltage and 300–430 A current within ca. 500 ns. This is the first study to report efficient oligopeptide synthesis in aqueous medium using nano-pulsed plasma (with thermal plasma being more efficient than non-thermal plasma) via DKP ring- opening.