カワムラ　クニオ   KAWAMURA Kunio   川村　邦男    所属   広島修道大学  人間環境学部    職種   教授
言語種別	英語
発行・発表の年月	1999/06
形態種別	学術論文
査読	査読有り
標題	Kinetics of hydrolysis of ribonucleotide polymers in aqueous solution at elevated temperatures: implications of chemical evolution of RNA and primitive ribonuclease
執筆形態	共著
掲載誌名	Viva Origino
掲載区分	国内
巻・号・頁	27(2),pp.107-118
担当範囲	Corresponding anthor
概要	The rate constants of hydrolysis of ribonuleoride homo- and copolymers were determined in the absence and presence of MgCl2 in pH8 aqueous solution at 60 -120 oC. The hydrolysis rate was enhanced by Mg2+ by 47 - 290 times, which was dependent on the type of nucleotide bases. Homopolymers poly(A) and poly(U) were less stable than poly(G) and poly(C0, poly(A)/poly(U) duplex, and copolymers poly(A,U,C) and poly(A,U) at 80oC. The temperature dependence of the rate constants pf poly(A) hydrolysis was determined and compared with the rate constants with ribonucleases.