カワムラ　クニオ   KAWAMURA Kunio   川村　邦男    所属   広島修道大学  人間環境学部    職種   教授
言語種別	英語
発行・発表の年月	2001/10
形態種別	学術論文
査読	査読有り
標題	Hisitidine and thermal copolymers of amino acids containing histidine as prebiotic inhibitor for the template-directed formation of oligoguanylate on a poly(C) template
執筆形態	共著
掲載誌名	Chem. Lett.
掲載区分	国内
巻・号・頁	pp.1071-1072
担当範囲	Corresponding anthor
著者・共著者	◎Kunio Kawamura, Kazuhiro Kuranoue
概要	Possibility of the cooperative chemical evolution of nucleic acids and proteins has been investigated using the template- directed formation of oligoguanylate with amino acids and thermal copolymers of amino acids, in which strong inhibition by histidine containing thermal copolymer and histidine itself was observed. The inhibition is regarded as prebiotic enzymatic activities for the hydrolysis of activated nucleotide monomer and the formation of pyrophospho-capped oligoguanylate.