オガタ　トモノリ   OGATA Tomonori   緒方　知徳    所属   広島修道大学  人間環境学部    職種   教授
言語種別	日本語
発行・発表の年月	2026/02
形態種別	学術論文
標題	Compensatory Overload Counters Fasting-Induced Anabolic Suppression in Rat Skeletal Muscle
執筆形態	共著
掲載誌名	人間環境学研究
掲載区分	国内
概要	Fasting suppresses anabolic signaling via mTORC1 and promotes proteolysis, whereas chronic mechanical loading activates mTORC1. We examined whether compensatory overload preserves anabolic signaling during fasting in rat plantaris muscle. Fasting decreased muscle mass and mTORC1/p70S6K phosphorylation, while overload increased them; when fasting was superimposed on overload, muscle loss was attenuated and mTORC1/p70S6K activation was largely maintained. Thus, mechanical loading can preserve anabolic signaling under energy deficit and mitigate fasting-induced atrophy in fast-twitch muscle.