カワムラ　クニオ   KAWAMURA Kunio   川村　邦男    所属   広島修道大学  人間環境学部    職種   教授
言語種別	英語
発行・発表の年月	2005/06
形態種別	学術論文
査読	査読有り
標題	Chemical evolution of RNA under hydrothermal conditions and the role of thermal copolymers of amino acids for the prebiotic degradation and formation of RNA
執筆形態	共著
掲載誌名	Adv. Space Res.
掲載区分	国外
巻・号・頁	35(9),pp.1626-1633
担当範囲	Corresponding author
著者・共著者	◎Kunio Kawamura, Minoru Nagahama, Kazuhiro Kuranoue
概要	The roles of thermal copolymers of amino acids (TCAA) were studied for the prebiotic degradation of RNA. A weak catalytic ability of TCAA consisted of Glu, L-Ala, L-Val, L-Glu, L-Asp, and optionally L-His was detected for the cleavage of the ribose phos- phodiester bond of a tetranucleotide in aqueous solution at 80 °C. The rate constants of the disappearance were determined in aqueous solutions using different pH buffer and TCAA. The degradation rates were enhanced 1.3–3.0 times in the presence of TCAA at pH 7.5 and 8.0 at 80 °C, while the hydrolysis of oligoguanylate (oligo(G)) was accelerated about 1.6 times at pH 8.0. On the other hand, our recent study on the influences of TCAA for the template-directed reaction of oligo(G) on a polycytidylic acid template showed that TCAA has an acceleration activity for the degradation of the activated nucleotide monomer and an accel- eration activity for the formation of G50 ppG capped oligo(G).