カワムラ　クニオ   KAWAMURA Kunio   川村　邦男    所属   広島修道大学  人間環境学部    職種   教授
言語種別	英語
発行・発表の年月	2006/09
形態種別	学術論文
査読	査読有り
標題	Inhibitory activity of thermal copolymers of amino acids for the metal-catalyzed hydrolysis of an RNA dinucleotide
執筆形態	共著
掲載誌名	Adv. Space Res.
掲載区分	国外
巻・号・頁	38(6),pp.1220-1226
担当範囲	Corresponding author
著者・共著者	◎Kunio Kawamura, Minoru Nagahama, Toshio Yao
概要	It is well known that the hydrolysis of RNA is substantially catalyzed by several metal ions. Although this fact poses a problem for the RNA world hypothesis, there may have been unknown pathways for the protection of RNA molecules against the hydrolytic degrada- tion under the primitive earth conditions. Thus, we have investigated whether or not thermal copolymers of amino acids (TCAA) inhibit the catalytic activity of metal ions for the RNA hydrolyses. The activities of metal ions that Fe(III) and Co(II) enhance somewhat the 30,50-cytidylylguanosine C30 pG hydrolysis and Ce(III) and Eu(III) accelerate greatly the C30 pG hydrolysis were notably reduced by TCAA. This fact indicates that protein-like molecules would have played important roles for the accumulation of RNA under the primitive earth conditions.