カワムラ　クニオ   KAWAMURA Kunio   川村　邦男    所属   広島修道大学  人間環境学部    職種   教授
言語種別	英語
発行・発表の年月	2007/02
形態種別	学術論文
査読	査読有り
標題	Kinetic analysis of oligo(C) formation from the 5'-monophosphorimidazolide of cytidine with Pb(II) ion catalyst at 10 – 75 oC
執筆形態	共著
掲載誌名	Origins Life Evol. Biosphere
掲載区分	国外
巻・号・頁	37(2),pp.153-165
担当範囲	Corresponding author
著者・共著者	◎Kunio Kawamura, Jun Maeda
概要	The temperature dependence of the rate constants for the formation of oligocytidylate (oligo(C)) from the 5′-monophosphorimidazolide of cytidine (ImpC) in the presence of Pb(II) ion catalyst has been investigated at 10–75°C. The rate constants for the formation of oligo(C) increased in the order of the formation of 2-mer<3-mer≤4-mer. While the rate constants of the formation of oligo(C) increased with increasing temperature, the yield of oligo(C) decreased with increasing temperature. This is due to the fact that the relative magnitude of the rate constants of the formation of 2-mer, 3-mer, and 4-mer to that of the hydrolysis of ImpC decreased with increasing temperature. The apparent activation energy were determined for the hydrolysis of ImpC. The significance of the temperature dependence of the formation rate constants of the model prebiotic formation of RNA is discussed.