カワムラ　クニオ   KAWAMURA Kunio   川村　邦男    所属   広島修道大学  人間環境学部    職種   教授
言語種別	英語
発行・発表の年月	2008/05
形態種別	学術論文
査読	査読有り
標題	One-step formation of oligopeptide-like molecules from Glu and Asp in hydrothermal environments
執筆形態	共著
掲載誌名	Naturwissenschaften
掲載区分	国外
巻・号・頁	95(5),pp.449-454
担当範囲	Corresponding author
著者・共著者	◎Kunio Kawamura, Masanori Shimahashi
概要	Biopolymer accumulation in the absence of enzymes is an essential step for the chemical evolution of primitive life-like systems, and successful simulation experiments of prebiotic biopolymer formation have sug- gested that oligopeptides could have formed near subma- rine hydrothermal vent environments on primitive earth. However, the yield and length of oligopeptides—typically limited to 6-mers—seems to be inadequate. One reason is the rapid formation of diketopiperazines (DKPs) from dipeptides. In this study, using a hydrothermal microflow reactor, we show that the one-step synthesis of oligopep- tide-like molecules of length up to 20-mers proceeds from Glu and Asp. Yields of up to 0.17–0.57% were obtained in an acidic solution within 183 s at 250–310°C, as evaluated by matrix-assisted laser desorption/ionization mass spec- trometry (MALDI-MS) analysis and different types of high- performance liquid chromatography (HPLC) analyses.