カワムラ　クニオ   KAWAMURA Kunio   川村　邦男    所属   広島修道大学  人間環境学部    職種   教授
言語種別	英語
発行・発表の年月	2008/09
形態種別	学術論文
査読	査読有り
標題	Kinetics and activation parameter analysis for the prebiotic oligocytidylate formation on Na+-montmorillonite at 0 – 100 °C
執筆形態	共著
掲載誌名	J. Phys. Chem. A
掲載区分	国外
巻・号・頁	112(35),pp.8015-8023
担当範囲	Corresponding author
著者・共著者	◎Kunio Kawamura, Jun Maeda
概要	The kinetic analysis of the temperature dependence of the formation of oligocytidylate (oligo(C)) from the 5′-monophosphorimidazolide moiety of cytidine (ImpC) in the presence of Na+-montmorillonite (Na+-Mont) catalyst has been carried out at 0-100 °C. The rate constants for the formation of oligo(C), hydrolysis of ImpC with and without Na+-Mont and degradation of oligo(C) were determined. Although the degradation of oligo(C) in the presence of Na+-Mont was slower than the formation of the 3-mer and longer oligo(C) on Na+-Mont, its yield decreased with temperature. This is mainly because the ratios of the rate constant of the 2-mer formation to those of ImpC hydrolysis and the 3-mer and 4-mer formation decrease with an increase in temperature. According to the kinetics and activation parameter analyses regarding the clay reaction and other prebiotic polymerase models, the possible pathways for the oligonucleotide formation are discussed and compared.