ニッタ　ユミコ   NITTA Yumiko   新田　由美子    所属   広島修道大学  健康科学部    職種   教授
言語種別	英語
発行・発表の年月	2007/07
形態種別	学術論文
査読	査読有り
標題	Intestinal tumorigenicity of mice carrying hemizygous Pax6, pax6<sey-4H>.
執筆形態	共著
掲載誌名	Exp. Anim.
掲載区分	国内
巻・号・頁	56,pp.289-294
頁数	6
担当範囲	all process
著者・共著者	◎Nitta Y., Yoshida K., Nakagata N., Nitta K., Harada T., Ishizaki F.
概要	The genotype-phenotype relationship in mice was examined experimentally using one of the small eye mutants, Pax6(Sey-4H), which deletes the chromosome 2 middle region, hemizygously. The genotyping indicated that the deleted region starts at a site 102.60 Mb from the centromere and has a length of 6.51 Mb, in which 12 known and 27 novel genes are located. Expecting the development of myeloid leukemia, gamma-irradiation was performed to female mutants at the age of 10 weeks. The mutants did not develop myeloid leukemia during the observation period of 18 months. Instead, they developed tumors in the alimentary tract spontaneously (56.0%). The tumor latency was shortened by the radiation exposure, but the tumor incidence of the gamma-irradiated group (62.5%) was as high as that of spontaneously developing tumors. Intraductal proliferation of the epithelium of the Wirsung duct was observed in the gamma-irradiated mutants (18.8%).
researchmap用URL	https://www.jstage.jst.go.jp/browse/expanim