ニッタ　ユミコ   NITTA Yumiko   新田　由美子    所属   広島修道大学  健康科学部    職種   教授
言語種別	英語
発行・発表の年月	2008/07
形態種別	学術論文
査読	査読有り
標題	Upregulation of c-myc gene accompanied by PU.1 deficiency in radiation-induced acute myeloid leukemia in mice.
執筆形態	共著
掲載誌名	Exp. Hematol.,
巻・号・頁	36,pp.871-885
頁数	15
担当範囲	Plan and do.
著者・共著者	Hirouchi T., Takabatake T., Yoshida K., Nitta Y., Nakamura M., Tanaka S., Ichinohe K., Ogis Y., Tanaka K.
概要	High-dose radiation exposure induces acute myeloid leukemia (AML) in C3H mice, most of which have a frequent hemizygous deletion around the D2Mit15 marker on chromosome 2. This region includes PU.1, a critical candidate gene for initiation of leukemogenesis. To identify novel cooperative genes with PU.1, relevant to radiation-induced leukemogenesis, we analyzed the copy number alterations of tumor-related gene loci by array CGH, and their expressions in primary and transplanted AMLs.The new finding on upregulation of c-myc and PU.1 in both and hemizygous PU.1-deficient AMLs and different genomic alterations detected by array CGH suggests that the molecular mechanism for development of radiation-induced AML should be different among three types of AML.
researchmap用URL	https://www.sciencedirect.com/journal/experimental-hematology