イシダ マリ   ISHIDA Mari   石田　万里    所属   広島修道大学  健康科学部    職種   教授
言語種別	英語
発行・発表の年月	2024/12
形態種別	学術論文
査読	査読有り
標題	Decreased plasma cell-free mitochondrial DNA may be a new biomarker of tachycardia-induced cardiomyopathy in patients with atrial fibrillation.
執筆形態	共著
掲載誌名	Int J Cardiol.
掲載区分	国外
巻・号・頁	417,pp.132579
著者・共著者	Miyamoto S, Tokuyama T, Okubo Y, Okamura S, Miyauchi S, Furutani M, Kobayashi Y, Odake Y, Oguri N, Uotani Y, Nakashima M, Akiyama R, Sakai T, Ishida M, Nakano Y.
概要	Tachycardia-induced cardiomyopathy (TIC) is a reversible cardiomyopathy caused by tachyarrhythmias, such as atrial fibrillation (AF) tachycardia. The pathogenesis of TIC remains incompletely understood, and there is currently no method to predict its development in patients. In this study, we show that cell-free mitochondrial DNA (mt-cfDNA) levels were significantly lower in the TIC group than in the non-TIC group. Persistent AF, coexisting diabetes mellitus, and decreased mt-cfDNA levels were independently associated with TIC. Decreased mt-cfDNA levels may serve as a novel biomarker for predicting TIC in patients with AF.