Department   Hiroshima shudo University  The Faculty of Human Environmental Studies
   Position   Professor
Language English
Publication Date 2022/05
Type Articles
Peer Review With peer review
Title Nano-pulsed discharge-plasma-induced abiotic oligopeptide formation from diketopiperazine
Contribution Type Co-Authored Publication
Journal Naturwissenschaften
Journal TypeAnother Country
Volume, Issue, Pages 109
Number of pages 6
Responsible for Corresponding author
Author and coauthor Mitsuru Sasaki*, Yuji Miyagawa, Kouki Nonaka, Ryota Miyanomae, Armando T. Quitain, Tetsuya Kida, Motonobu Goto, Tetsuo Honma, Tomohiro Furusato, Kunio Kawamura*
Details Conventional oligopeptide synthesis techniques involve environmentally harmful procedures and materials. In addition, the efficient accumulation of oligopeptides under Hadean Earth environments regarding the origin of life remains still unclear. In these processes, the formation of diketopiperazine is a big issue due to the strong inhibition for further elongation beyond dipeptides. Here, we show an efficient pathway for oligopeptide formation using a specially designed experimental setup to run both thermal and non-thermal dis- charge plasma, generated by nano-pulsed electric discharge with 16–23 kV voltage and 300–430 A current within ca. 500 ns. This is the first study to report efficient oligopeptide synthesis in aqueous medium using nano-pulsed plasma (with thermal plasma being more efficient than non-thermal plasma) via DKP ring- opening.