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KAWAMURA Kunio
Department Hiroshima shudo University The Faculty of Human Environmental Studies Position Professor |
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| Language | English |
| Publication Date | 2022/10 |
| Type | Articles |
| Peer Review | With peer review |
| Title | Life on minerals: Binding behaviors of oligonucleotides on zirconium silicate and its inhibitory activity for the self-cleavage of hammerhead ribozyme |
| Contribution Type | Co-Authored Publication |
| Journal | Life |
| Journal Type | Another Country |
| Publisher | MDPI |
| Volume, Issue, Pages | 12,pp.1689 |
| Number of pages | 16 |
| Responsible for | Corresponding author |
| Author and coauthor | Kunio Kawamura, Jean-François Lambert, Louis M. P. Ter-Ovanessian, Jacques Vergne, Guy Hervé, Marie-Christine Maurel |
| Details | The role of minerals in the chemical evolution of RNA molecules is an important issue when considering the early stage of the Hadean Earth. In particular, the interaction between functional ribozymes and ancient minerals under simulated primitive conditions is a recent research focus. We are currently attempting to design a primitive RNA metabolic network which would function with minerals, and believe that the simulated chemical network of RNA molecules would be useful for evaluation of the chemical evolution from a simple RNA mixture to an RNA-based life-like system. The present study suggests that the chemical evolution of functional RNA molecules requires specific conformational binding, resulting in efficient ribozyme function as well as zirconium silicate for the chemical evolution of biomolecules. |