Department   Hiroshima shudo University  The Faculty of Human Environmental Studies
   Position   Professor
Language English
Publication Date 2022/10
Type Articles
Peer Review With peer review
Title Life on minerals: Binding behaviors of oligonucleotides on zirconium silicate and its inhibitory activity for the self-cleavage of hammerhead ribozyme
Contribution Type Co-Authored Publication
Journal Life
Journal TypeAnother Country
Publisher MDPI
Volume, Issue, Pages 12,pp.1689
Number of pages 16
Responsible for Corresponding author
Author and coauthor Kunio Kawamura, Jean-François Lambert, Louis M. P. Ter-Ovanessian, Jacques Vergne, Guy Hervé, Marie-Christine Maurel
Details The role of minerals in the chemical evolution of RNA molecules is an important issue when considering the early stage of the Hadean Earth. In particular, the interaction between functional ribozymes and ancient minerals under simulated primitive conditions is a recent research focus. We are currently attempting to design a primitive RNA metabolic network which would function with minerals, and believe that the simulated chemical network of RNA molecules would be useful for evaluation of the chemical evolution from a simple RNA mixture to an RNA-based life-like system. The present study suggests that the chemical evolution of functional RNA molecules requires specific conformational binding, resulting in efficient ribozyme function as well as zirconium silicate for the chemical evolution of biomolecules.